

Some info about Colchicine (Colcrys) medication in general:
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Because Colchicine (Colcrys) was developed prior to federal regulations requiring FDA review of all marketed drug products, not all uses for Colchicine have been approved by the FDA. As of 2009, Colcrys is the only brand of Colchicine (Colcrys) that has been approved by the FDA. The Colcrys brand of Colchicine is FDA-approved to treat gout in adults, and to treat a genetic condition called Familial Mediterranean Fever in adults and children who are at least 4 years old.
The current FDA-approved dosage for gout flare is substantially lower than what has been historically used clinically. doses higher than 1.8 mg over a 1 hour period for gout flare are not proven more effective and are not recommended.
Patients with renal or liver impairment should not be given Colchicine (Colcrys) in conjunction with P-gp or strong CYP450 3A4 inhibitors. In these patients, life-threatening and fatal Colchicine (Colcrys) toxicity has been reported with Colchicine (Colcrys) taken in therapeutic doses.
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And here are several testimonials about Colchicine drug from some patients:
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I was a virgin gout sufferer and the doctor gave me the perscription and reduced the swelling immediately. I am very pleased with the drug and will keep it close by always. No diarria or stomach problems.
I have taken Colchicine (Colcrys) off and on during flares, and it seems that it has helped , but it sure makes intestinal problems. I don't want to go out anywhere while taking this medication.
This is my 3rd and worse bout with gout. My Dr. prescribed this medication and forewarned me that it MAY cause diarahea. He suggested one 0.6 mg pill every four hours instead of every one to two hours. It took just a little longer but after taking this for 18 hours the front of my foots swelling has gone down 50% and the pain has subsided by over 75%. When this attack is over , he is starting my on Allopurinol to avoid this in the future. In short, Colchicine is a god sent medication.
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Also if you're not tired of reading - here are some interesting quotes about health from some well-known people:
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Bernadette Peters: It was one of the most exciting, perfect evenings of my life, my solo debut at Carnegie Hall. And knowing we were all there to raise money for Gay Men's Health Crisis made the evening an extraordinary experience.
Karen Duffy: I never expected in a million years that I would have the honor to become an advocate of women's health care and education, and I'd dive on a live grenade to get this message out, so thank you for this forum.
Carol Bellamy: In choosing global corporate partners UNICEF emphasises compatibility with our core values and looks to build alliances that advance our mission of ensuring the health, education, equality and protection for all the world's children.
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And here we have more words about Colchicine pills should be said:
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Renal dosage Adjustments. Familial Mediterranean Fever: Mild (CrCl 50 to 80 mL/min) to moderate (CrCl 30 to 50 mL/min) renal impairment: No dose adjustment required, but patients should be monitored closely for adverse effects. dose reduction may be necessary. Severe (CrCl less than 30 mL/min) renal impairment: Dosage should be started at 0.3 mg/day; any increase in dosage should be done with adequate monitoring of the patient for adverse effects. In patients with renal impairment who are taking protease inhibitors for the treatment of HIV-1 infection, the FDA has recommended against the coadministration of Colchicine (Colcrys).
Usual Adult dosage for Acute Gout. Oral: Initial: Gout Flare: 1.2 mg orally at the first sign of the flare followed by 0.6 mg one hour later. Maximum: Gout Flare: 1.8 mg orally over a one hour period.
Usual Adult dosage for Constipation - Chronic - 0.6 mg orally three times daily for 4 weeks. Usual Adult dosage for Sweet's Syndrome - 0.6 mg orally twice daily.
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And of course a few more feedbacks about Colchicine medicine from different patients:
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Colchicine for Gout, Acute: Gout is so painful. After first doses of Colchicine had immediate relief. I had fallen on my knee and was being treated for osteoarthritis with no relief. Went to arthritis healthcare professional who told me it was gout in my knee. Went on Colcyrs and I can walk again.
I thought gout so I talked to the health care professional again and she looked at it and said possible gout and Rx'ed me with Colchicine (Colcrys) for 5 days. AFTER 2 DAYS I WAS PAIN FREE!! NO PAIN IN MY FEET, SHOULDERS, ELBOWS, KNEES, HANDS, MUSCLES. ANYWHERE. I COULD RUN UP AND DOUM THE STEPS. This was a miricle to me. I have been pain free up till about 2 wks. ago. I am breaking down and giong to have the uric acid blood test. If it is gout then she will Rx allipurinol(sp)? If I dont have gout then I dont know what I do have but Colchicine was my miracle drug.
While on Azathioprine my awesome Rheumatologist suggested Colchicine because my mucosal ulcerations were not going away. This worked wonders and since I have been on it have had constant dependable results. I am off the Azathioprine and on Humira but still taking Colchicine (Colcrys). This drug I have to say has given me the most improvement of my quality of life.
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